Basic Information
VIS ID
TVIS10012104
Fusion event
HBV-chr4 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
Polymerase|
Start
2813
Orient
+
Integrated sequence
CATCTAGTTAATCATTACTTCCAAACTAGACACTATTTACACACTCTATGGAAGGCGGGTATATTATATAAGAGAGAAACAACACATAGCGCCTCATTTT| |GTGGGTCACCATATTCTTGGGAACAAGATCTACAGCATGGGGCAGAATCTTTCCACCAGCAATCCTCTGGGATTCTTTCCCGACCACCAGTTGGATCCAG
Host Sequence
Chromosome
chr4
Cytoband
p14
Reference genome
GRCh37/hg19
Start
36772300/36770678 (Hg38)
End
36772300/36770678 (Hg38)
Orient
+
Location type
Intergenic
Nearest miRNA
hsa-mir-12113/Upstream/344250; hsa-mir-1243/Downstream/471232;
Nearest TSS
ENST00000502981/Upstream/128778; ENST00000501725/Downstream/307899;
Nearest CpG islands
None/Target, chr4-CpG: 46/Upstream/525911, chr4-CpG: 173/Downstream/472950
Nearby gene
DTHD1(-424922) ; MIR4801(+471232) ;
Upstream sequence
gatacagattaacaggcaagtggaagggatgcatagggcaaattatcaggaaagcagctcaaagcttctgtgccctctcaaggcgcgccaccctgtaagc
Downstream sequence
tgaaatggtggagcaaagcaagaaactcgagaaagtccctctcctggtgcatgccaaggaaggagaccagcagctgttgtggaaaagTCATTGAGACCTA
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
Curate