Basic Information
VIS ID
TVIS10012111
Fusion event
HBV-chr5 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
X protein|precore/core protein|
Start
1826
Orient
-
Integrated sequence
AAAGACTGGGAGGAGTTGGGGGAGGAGATTAGGTTAAAGGTCTTTGTACTAGGAGGCTGTAGGCATAAATTGGTCTGCGCACCAGCACCATGCAACTTTT| |TCACCTCTGCCTAATCATCTCTTGTTCATGTCCTACTGTTCAAGCCTCCAAGCTGTGCCTTGGGTGGCTTTGGGGCATGGACATCGACCCTTATAAAGAA
Host Sequence
Chromosome
chr5
Cytoband
q23.2
Reference genome
GRCh37/hg19
Start
126841358/127505666 (Hg38)
End
126841358/127505666 (Hg38)
Orient
+
Location type
Intergenic
Nearest miRNA
hsa-mir-10397/Upstream/8350950; hsa-mir-103a-1/Downstream/1592022;
Nearest TSS
ENST00000502646/Upstream/27371; ENST00000512871/Downstream/11943;
Nearest CpG islands
None/Target, chr5-CpG: 87/Upstream/214457, chr5-CpG: 54/Downstream/11935
Nearby gene
MEGF10(-44448) ; PRRC1(+11951) ;
Upstream sequence
tctggccccagccatctctccagcctcatttctgGTGACTCCCAGATCTGGCCCCAGCCATGTCTCTAGACTCCAAACTTATTCCTTATAATGCTCCCAC
Downstream sequence
cccagctactctggaggctgaggcaggagaatcccttgaacccaggagacggaggttgtagtgagccgagatcatgccacctcactccagcctgagtgac
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
Curate