VISDB Viral Integration Site DataBase

VIS ID

TVIS10012117

Fusion event

HBV-PPP1R14C integration

Validated

No

Detection method

NGS

Data source

Curated

Sample type

Disease

Hepatocellular carcinoma (HCC)

Quality evaluation

Normal

Reported year

2018

PubMed ID

Virus name

HBV

Reference genome

Region type

S protein|Polymerase|large S protein|middle S protein|

Start

500

Orient

+

Integrated sequence

TCTTCCTCTTCATCCTGCTGCTATGCCTCATCTTCTTGTTGGTTCTTCTGGACTATCAAGGTATGTTGCCCGTTTGTCCTCTAATTCCAGGATCCTCAAC| |AACCAGCACGGGACCATGCCGGACCTGCATGACTACTGCTCAAGGAACCTCTATGTATCCCTCCTGTTGCTGTACCAAACCTTCGGACGGAAATTGCACC

Chromosome

chr6

Cytoband

q25.1

Reference genome

Start

End

150467497/150146361 (Hg38)

Orient

-

Location type

Intronic

Target gene

miRNAs that regulate target gene

hsa-mir-340-5p ; hsa-mir-29c-3p ; hsa-mir-130a-3p ; hsa-mir-191-5p ; hsa-mir-134-3p ; hsa-mir-301a-3p ; hsa-mir-130b-3p ; hsa-mir-454-3p ; hsa-mir-301b-3p ; hsa-mir-4295 ; hsa-mir-3666 ; hsa-mir-4671-3p ; hsa-mir-7114-5p ; hsa-mir-526b-3p ; hsa-mir-520e ; hsa-mir-520c-3p ; hsa-mir-520b ; hsa-mir-653-3p ; hsa-mir-4420 ; hsa-mir-181b-3p ; hsa-mir-181b-2-3p ; hsa-mir-4672 ; hsa-mir-222-3p ; hsa-mir-221-3p ; hsa-mir-548v ; hsa-mir-187-5p ; hsa-mir-3166 ; hsa-mir-6890-3p ; hsa-mir-3681-3p ; hsa-mir-216a-3p ; hsa-mir-128-3p ; hsa-mir-520f-3p ; hsa-mir-302c-3p ; hsa-mir-6768-5p ; hsa-mir-4652-3p ; hsa-mir-4743-3p ; hsa-mir-142-3p ; hsa-mir-6073 ; hsa-mir-6757-3p ; hsa-mir-30d-5p

Nearest miRNA

hsa-mir-10398/Upstream/9462478; hsa-mir-1202/Downstream/956314;

Nearest TSS

Nearest CpG islands

None/Target, chr6-CpG: 120/Upstream/2495, chr6-CpG: 124/Downstream/453549

Upstream sequence

acaaattaagcagctctggttctagggtgcccttaatagtggcagtctcaatgcaactagctgcatttacaacataggctgaatcacaaacaatattaat

Downstream sequence

acatctgtctaaatgtttaaaacttatgagttaaactaacaacatttgtataaaatttcttctgtccactgatcttgacagctacatcttcataatgacc