VISDB Viral Integration Site DataBase

VIS ID

TVIS10012118

Fusion event

HBV-GLI3 integration

Validated

No

Detection method

NGS

Data source

Curated

Sample type

Disease

Hepatocellular carcinoma (HCC)

Quality evaluation

Normal

Reported year

2018

PubMed ID

Virus name

HBV

Reference genome

Region type

X protein|precore/core protein|

Start

1826

Orient

-

Integrated sequence

AAAGACTGGGAGGAGTTGGGGGAGGAGATTAGGTTAAAGGTCTTTGTACTAGGAGGCTGTAGGCATAAATTGGTCTGCGCACCAGCACCATGCAACTTTT| |TCACCTCTGCCTAATCATCTCTTGTTCATGTCCTACTGTTCAAGCCTCCAAGCTGTGCCTTGGGTGGCTTTGGGGCATGGACATCGACCCTTATAAAGAA

Chromosome

chr7

Cytoband

p14.1

Reference genome

Start

End

42204743/42165144 (Hg38)

Orient

+

Location type

Intronic

Target gene

miRNAs that regulate target gene

hsa-mir-1301-3p ; hsa-mir-148b-3p ; hsa-mir-93-5p ; hsa-mir-200c-3p ; hsa-mir-378a-3p ; hsa-mir-506-3p ; hsa-mir-133b

Nearest miRNA

hsa-mir-1183/Upstream/5245712; hsa-mir-10399/Downstream/985751;

Nearest TSS

Nearest CpG islands

None/Target, chr7-CpG: 39/Upstream/198621, chr7-CpG: 163/Downstream/71260

Nearest cancer related gene

GLI3(OG, No orient, 0)

Upstream sequence

ATGTTAGGTCGGCAAACACTGTCTGCTACAGTTCATAACGTAGTTTCGAGAGCCTTCAAAAGTATTAATGACAAACTAACGTTTGGAATATGGGGAACAC

Downstream sequence

GCAGTGagcctgggcaacagagtgaaactgtgtccaaaaaaaaaaaaagaaaaaaCAAATCACTATTGAGTAGGGTGCGCTCTCTGGTGGGTTATAGCAG