Basic Information
VIS ID
TVIS10012119
Fusion event
HBV-PSPHP1 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
X protein|precore/core protein|
Start
1826
Orient
-
Integrated sequence
AAAGACTGGGAGGAGTTGGGGGAGGAGATTAGGTTAAAGGTCTTTGTACTAGGAGGCTGTAGGCATAAATTGGTCTGCGCACCAGCACCATGCAACTTTT| |TCACCTCTGCCTAATCATCTCTTGTTCATGTCCTACTGTTCAAGCCTCCAAGCTGTGCCTTGGGTGGCTTTGGGGCATGGACATCGACCCTTATAAAGAA
Host Sequence
Chromosome
chr7
Cytoband
p11.2
Reference genome
GRCh37/hg19
Start
55833926/55766233 (Hg38)
End
55833926/55766233 (Hg38)
Orient
-
Location type
Intronic
Fragile sites / regions
FRA7A
Target gene
PSPHP1
Nearest miRNA
hsa-mir-1183/Upstream/10884433; hsa-mir-10399/Downstream/1189552;
Nearest TSS
ENST00000635602/Upstream/172456; ENST00000484120/Downstream/96522;
Nearest CpG islands
None/Target, chr7-CpG: 39/Upstream/24925, chr7-CpG: 41/Downstream/121009
Nearby gene
FKBP9P1(-61666) ; SEPTIN14(+27311) ;
Upstream sequence
atggcacgatctcggctcaccgcaacctccacctcctgggttcaagtgattctcctgccccggcctcctgagtagctgggactacaggcatacaccacca
Downstream sequence
tacaggtgcccatcaccacgcctggctaatttttgtaCAGTGCCCAACCGTACTTTTGTTTTAGACAGCTGGTTTGTcctataatcccagcactttggga
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
Curate