Basic Information
VIS ID
TVIS10012121
Fusion event
HBV-LOC101927997 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
Polymerase|
Start
2465
Orient
-
Integrated sequence
CCCCTAGAAGAAGAACTCCCTCGCCTCGCAGACGAAGGTCTCAATCGCCGCGTCGCAGAAGATCTCAATCTCGGGAATCTCAATGTTAGTATTCCTTGGA| |CTCATAAGGTGGGGAACTTTACTGGGCTTTATTCTTCTACTGTACCTGTCTTTAATCCTCATTGGAAAACACCATCTTTTCCTAATATACATTTACACCA
Host Sequence
Chromosome
chr8
Cytoband
p23.1
Reference genome
GRCh37/hg19
Start
7382935/7525413 (Hg38)
End
7382935/7525413 (Hg38)
Orient
+
Location type
Intronic
Target gene
LOC101927997
Nearest miRNA
hsa-mir-3674/Upstream/780169; hsa-mir-10400/Downstream/563528;
Nearest TSS
ENST00000518652/Upstream/29567; ENST00000533250/Downstream/14215;
Nearest CpG islands
None/Target, chr8-CpG: 109/Upstream/170045, chr8-CpG: 20/Downstream/3256
Nearby gene
DEFB107B(-16102) ; FAM90A7P(+30725) ;
Upstream sequence
tccagtcttcttgagtgatatctctggatgtgggagtgaaccaaatgaatagcgcctgaagcgaacccctagcaaaccacagcagccctacagaggaggg
Downstream sequence
GAGGCCATAGGATCCTGCCAGCATGGGGGGTTTCTGGACCTGTCAGGGGGCTCATCTCAGGTTTCCTCCCACTGTCGATCTATGTTCCCTCTCTAAATGA
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
Curate