Basic Information
VIS ID
TVIS10012122
Fusion event
HBV-LOC101929013 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
precore/core protein|Core and e antigen|Polymerase|
Start
2369
Orient
-
Integrated sequence
GAGTGTGGATTCGCACTCCTCCAGCTTATAGACCACCAAATGCCCCTATCCTATCAACACTTCCGGAGACTACTGTTGTTAGACGACGAGGCAGGTCCCC| |TAGAAGAAGAACTCCCTCGCCTCGCAGACGAAGGTCTCAATCGCCGCGTCGCAGAAGATCTCAATCTCGGGAATCTCAATGTTAGTATTCCTTGGACTCA
Host Sequence
Chromosome
chr8
Cytoband
p23.1
Reference genome
GRCh37/hg19
Start
7653028/7795506 (Hg38)
End
7653028/7795506 (Hg38)
Orient
-
Location type
Intronic
Target gene
LOC101929013
Nearest miRNA
hsa-mir-3674/Upstream/1050262; hsa-mir-10400/Downstream/293435;
Nearest TSS
ENST00000518652/Upstream/14093; ENST00000335186/Downstream/20210;
Nearest CpG islands
None/Target, chr8-CpG: 109/Upstream/3163, chr8-CpG: 43/Downstream/159492
Nearby gene
FAM90A10P(-24193) ; DEFB107A(+16214) ;
Upstream sequence
cgggggggcgccaggggcctcccacttattctacacctctcatgtctcttcaccatgccagactagagtcaagctcaacagggtcttctttccccgctga
Downstream sequence
GAGAGGGAACATAGATCGACAGTGGGAGGAAACCTGAGATGAGCCCCCTGACAGGTCCAGAAACCCCCCATGCTGGCAGGATCCTATGGCCTCCACTGTG
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
Curate