Basic Information
VIS ID
TVIS10012123
Fusion event
HBV-LOC105375920 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
X protein|precore/core protein|
Start
1826
Orient
-
Integrated sequence
AAAGACTGGGAGGAGTTGGGGGAGGAGATTAGGTTAAAGGTCTTTGTACTAGGAGGCTGTAGGCATAAATTGGTCTGCGCACCAGCACCATGCAACTTTT| |TCACCTCTGCCTAATCATCTCTTGTTCATGTCCTACTGTTCAAGCCTCCAAGCTGTGCCTTGGGTGGCTTTGGGGCATGGACATCGACCCTTATAAAGAA
Host Sequence
Chromosome
chr8
Cytoband
q21.13
Reference genome
GRCh37/hg19
Start
81137526/80225291 (Hg38)
End
81137526/80225291 (Hg38)
Orient
-
Location type
Intronic
Target gene
LOC105375920
Nearest miRNA
hsa-mir-12123/Upstream/893017; hsa-mir-10400/Downstream/16098;
Nearest TSS
ENST00000518652/Upstream/6761; ENST00000522044/Downstream/5881;
Nearest CpG islands
None/Target, chr8-CpG: 109/Upstream/53469, chr8-CpG: 19/Downstream/40415
Nearby gene
TPD52(-53690) ; MIR5708(+16098) ;
Upstream sequence
ttgtctcagaaactgcttgccaaggaactcaatctgtgaGAGGAATGATAGGGCATCATATCAGAAACTTATTATCCAATGATTTAGGAGAGGAGAAAAA
Downstream sequence
tacaggtgcccatcaccacgcctggctaatttttgtatttgtagtagagatggggtttcaccatgttggccagtctggtcttgaactcctggcctcaagt
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
Curate