Basic Information
VIS ID
TVIS10012150
Fusion event
HBV-chrY integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
Polymerase|
Start
2793
Orient
+
Integrated sequence
TTAAACCTTATTATCCAGAACATCTAGTTAATCATTACTTCCAAACTAGACACTATTTACACACTCTATGGAAGGCGGGTATATTATATAAGAGAGAAAC| |AACACATAGCGCCTCATTTTGTGGGTCACCATATTCTTGGGAACAAGATCTACAGCATGGGGCAGAATCTTTCCACCAGCAATCCTCTGGGATTCTTTCC
Host Sequence
Chromosome
chrY
Cytoband
q12
Reference genome
GRCh37/hg19
Start
58870181/56720688 (Hg38)
End
58870181/56720688 (Hg38)
Orient
-
Location type
Intergenic
Nearest miRNA
hsa-mir-12120/Upstream/43241422;
Nearest TSS
ENST00000430575/Upstream/30992198;
Nearest CpG islands
None/Target, chrY-CpG: 62/Upstream/30093291, chrY-CpG: 36/Downstream/346957
Nearby gene
SPRY3(+230276) ;
Upstream sequence
tccattagcggacattccattccaatgcattccattccattccatagcattccattgcattcgattccattccatttgatgtcattccatttgatgccat
Downstream sequence
attccattgatttgattccattcagtttgattccattccgtgaaatttcgttccattctattccattgcattactttccattcaattccattccatttca
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
Curate