Basic Information
VIS ID
TVIS10012156
Fusion event
HBV-chrY integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
Polymerase|
Start
2776
Orient
+
Integrated sequence
ACCATTGGATAAGGGTATTAAACCTTATTATCCAGAACATCTAGTTAATCATTACTTCCAAACTAGACACTATTTACACACTCTATGGAAGGCGGGTATA| |TTATATAAGAGAGAAACAACACATAGCGCCTCATTTTGTGGGTCACCATATTCTTGGGAACAAGATCTACAGCATGGGGCAGAATCTTTCCACCAGCAAT
Host Sequence
Chromosome
chrY
Cytoband
q12
Reference genome
GRCh37/hg19
Start
58880631/56710238 (Hg38)
End
58880631/56710238 (Hg38)
Orient
-
Location type
Intergenic
Nearest miRNA
hsa-mir-12120/Upstream/43230972;
Nearest TSS
ENST00000430575/Upstream/30981748;
Nearest CpG islands
None/Target, chrY-CpG: 62/Upstream/30082841, chrY-CpG: 36/Downstream/357407
Nearby gene
SPRY3(+219826) ;
Upstream sequence
ccattctattccagtccattagttttgactccattgcattcgagtgcattccattccgtggctgtccattccattccgtttgatgccattccatacgatt
Downstream sequence
tccattccattagaggacattccattccaatgcattccattccattccatagcattccactgcattcgattccattccatttgatgccattacatttgat
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
Curate