Basic Information
VIS ID
TVIS10012182
Fusion event
HBV-LINC02567 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
X protein|
Start
1663
Orient
-
Integrated sequence
CTCATCTGCCGGACCGTGTGCACTTCGCTTCACCTCTGCACGTCGCATGGAGACCACCGTGAACGCCCACCAAATATTGCCCAAGGTCTTACATAAGAGG| |ACTCTTGGACTCTCAGCAATGTCAACGACCGACCTTGAGGCATACTTCAAAGACTGTTTGTTTAAAGACTGGGAGGAGTTGGGGGAGGAGATTAGGTTAA
Host Sequence
Chromosome
chr1
Cytoband
p31.1
Reference genome
GRCh37/hg19
Start
77235885/76770200 (Hg38)
End
77235885/76770200 (Hg38)
Orient
+
Location type
Intronic
Fragile sites / regions
FRA1L
Target gene
LINC02567
Nearest miRNA
hsa-mir-101-1/Upstream/5702484; hsa-mir-11399/Downstream/289943;
Nearest TSS
ENST00000473358/Upstream/133323; ENST00000496845/Downstream/9067;
Nearest CpG islands
None/Target, chr1-CpG: 111/Upstream/972982, chr1-CpG: 112/Downstream/97226
Nearby gene
ST6GALNAC3(-139216) ; ST6GALNAC5(+97301) ;
Upstream sequence
ACTGAGTACTACAGAAATCCAAAGGGTTGTTTTTGCTTCTTTATTCTTGTCATTGGATACCCAACAGTTAAGTTGGCAGAGACACTCAGATGTTACTAGG
Downstream sequence
CCTCAACATATTTAATTACAAACCCACTATTCAAGGAATTCAGAGACCAAGATGTTAATATGTGGAGATTCACAGCCACTGTAATCTCAGTGCTTGCCAC
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
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