Expression analysis of TCGA samples
Basic Information
VIS ID
TVIS10012185
Fusion event
HBV-AKR1E2 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
Virus Sequence
Virus name
HBV
Reference genome
Region type
X protein|precore/core protein|
Start
1820
Orient
-
Integrated sequence
TTGTTTAAAGACTGGGAGGAGTTGGGGGAGGAGATTAGGTTAAAGGTCTTTGTACTAGGAGGCTGTAGGCATAAATTGGTCTGCGCACCAGCACCATGCA| |ACTTTTTCACCTCTGCCTAATCATCTCTTGTTCATGTCCTACTGTTCAAGCCTCCAAGCTGTGCCTTGGGTGGCTTTGGGGCATGGACATCGACCCTTAT
Host Sequence
Chromosome
chr10
Cytoband
p15.1
Reference genome
Start
End
4940004/4897812 (Hg38)
Orient
-
Location type
ncRNA_intronic
Target gene
miRNAs that regulate target gene
Nearest miRNA
hsa-mir-5699/Upstream/906553; hsa-mir-107/Downstream/1254384;
Nearest CpG islands
None/Target, chr10-CpG: 68/Upstream/71207, chr10-CpG: 54/Downstream/514656
Upstream sequence
cttttacactgttggtgggactgtaaactagttcaaccattgtggaagacagtgtggcgattcctcagggatcttgaactagaaataccatttgacccag
Downstream sequence
caatcccattactgggtaaatacccaaaggattataaaacatgctgctgtaaagacacatgcgcacgtatgtttattgcggcactattcagaatagcaaa
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.