Basic Information
VIS ID
TVIS10012187
Fusion event
HBV-PARGP1 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
precore/core protein|Core and e antigen|
Start
2254
Orient
+
Integrated sequence
GTAGTCAGTTATGTCAACACTAATATGGGCCTAAAGTTCAGGCAACTCTTGTGGTTTCACATTTCTTGTCTCACTTTTGGAAGAGAAACAGTTATAGAGT| |ATTTGGTGTCTTTCGGAGTGTGGATTCGCACTCCTCCAGCTTATAGACCACCAAATGCCCCTATCCTATCAACACTTCCGGAGACTACTGTTGTTAGACG
Host Sequence
Chromosome
chr10
Cytoband
q11.22
Reference genome
GRCh37/hg19
Start
51630537/45965302 (Hg38)
End
51630537/45965302 (Hg38)
Orient
+
Location type
Intronic
Fragile sites / regions
FRA10G
Target gene
PARGP1
Nearest miRNA
hsa-mir-1265/Upstream/801214; hsa-mir-107/Downstream/3020210;
Nearest TSS
ENST00000439456/Upstream/111427; ENST00000580018/Downstream/7147;
Nearest CpG islands
None/Target, chr10-CpG: 68/Upstream/139160, chr10-CpG: 83/Downstream/6593
Nearby gene
TIMM23(-7151) ; AGAP6(+117541) ;
Upstream sequence
ttgtatttttagtagagatggggtttcaccgggttagccaggatggtctcgatctcctgacctcgtgatctgcctgcctcgacctcccaaagtgctggga
Downstream sequence
ttacaggtgtgagccactgcgcccggccagtctgtgtctttaagatacttacagtgtagcagtggccacagacacaaaaacacataattactgcctggtg
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
Curate