Basic Information
VIS ID
TVIS10012190
Fusion event
HBV-TASOR2 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
X protein|
Start
1707
Orient
-
Integrated sequence
GCATGGAGACCACCGTGAACGCCCACCAAATATTGCCCAAGGTCTTACATAAGAGGACTCTTGGACTCTCAGCAATGTCAACGACCGACCTTGAGGCATA| |CTTCAAAGACTGTTTGTTTAAAGACTGGGAGGAGTTGGGGGAGGAGATTAGGTTAAAGGTCTTTGTACTAGGAGGCTGTAGGCATAAATTGGTCTGCGCA
Host Sequence
Chromosome
chr10
Cytoband
p15.1
Reference genome
GRCh37/hg19
Start
5763717/5721754 (Hg38)
End
5763717/5721754 (Hg38)
Orient
+
Location type
Intronic
Target gene
TASOR2
miRNAs that regulate target gene
hsa-mir-26b-5p ; hsa-mir-504-5p ; hsa-mir-149-5p ; hsa-mir-29a-5p ; hsa-mir-142-3p ; hsa-mir-320a ; hsa-mir-340-5p ; hsa-mir-524-5p ; hsa-mir-520d-5p ; hsa-mir-513a-3p ; hsa-mir-320b ; hsa-mir-320c ; hsa-mir-513c-3p ; hsa-mir-320d ; hsa-mir-4280 ; hsa-mir-3606-3p ; hsa-mir-3674 ; hsa-mir-4429 ; hsa-mir-6073 ; hsa-mir-6512-5p ; hsa-mir-4330 ; hsa-mir-4699-3p ; hsa-mir-106a-3p ; hsa-mir-542-3p ; hsa-mir-4504 ; hsa-mir-4252 ; hsa-mir-549a
Nearest miRNA
hsa-mir-5699/Upstream/1730495; hsa-mir-107/Downstream/430442;
Nearest TSS
ENST00000439456/Upstream/7331; ENST00000532080/Downstream/5072;
Nearest CpG islands
None/Target, chr10-CpG: 68/Upstream/36020, chr10-CpG: 132/Downstream/90989
Upstream sequence
actaataaatgtggaaagattgataaattagaagatcagcatttgacaacaccataataatcaaccagtgtgtgctaaaaacaggtgaaagtttaatagt
Downstream sequence
atttgcatatcttacaacatttccccactacttgcttattaatcacaaaggaaacaatgcagacttaccagtggagtaaactggcagataccatcttaac
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
Curate