Basic Information
VIS ID
TVIS10012197
Fusion event
HBV-LOC112268063 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
S protein|Polymerase|large S protein|middle S protein|
Start
246
Orient
-
Integrated sequence
TGCGCTGAACATGGAGAACATCACATCAGGATTCCTAGGACCCCTTCTCGTGTTACAGGCGGGGTTTTTCTTGTTGACAAGAATCCTCACAATACCGCAG| |AGTCTAGACTCGTGGTGGACTTCTCTCAATTTTCTAGGGGGAACTACCGTGTGTCTTGGCCAAAATTCGCAGTCCCCAACCTCCAATCACTCACCAACCT
Host Sequence
Chromosome
chr10
Cytoband
q23.2
Reference genome
GRCh37/hg19
Start
89247766/87488009 (Hg38)
End
89247766/87488009 (Hg38)
Orient
+
Location type
Intronic
Fragile sites / regions
FRA10D
Target gene
LOC112268063
Nearest miRNA
hsa-mir-1265/Upstream/1223221; hsa-mir-107/Downstream/15872;
Nearest TSS
ENST00000439456/Upstream/63217; ENST00000472891/Downstream/16866;
Nearest CpG islands
None/Target, chr10-CpG: 68/Upstream/132584, chr10-CpG: 101/Downstream/16604
Nearby gene
FAM245A(-80309) ; MIR4678(+15872) ;
Upstream sequence
CAAAGAATTTCCTCTAGATTTGCTATTGTTTGCAAAATATATAgcggtggctcacgcctgtaatcccaacactttgggaggccaaggtgggtggatcacg
Downstream sequence
aggtcaggagatcgaagccatcctggctaacacagtgaaaccccgtctctactaaaaatacaaaaaattagctgggcgtggtggcacgtgcctgtagtcc
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
Curate