VISDB Viral Integration Site DataBase

VIS ID

TVIS10012202

Fusion event

HBV-RTN3 integration

Validated

No

Detection method

NGS

Data source

Curated

Sample type

Disease

Hepatocellular carcinoma (HCC)

Quality evaluation

Normal

Reported year

2018

PubMed ID

Virus name

HBV

Reference genome

Region type

X protein|

Start

1787

Orient

-

Integrated sequence

ACGACCGACCTTGAGGCATACTTCAAAGACTGTTTGTTTAAAGACTGGGAGGAGTTGGGGGAGGAGATTAGGTTAAAGGTCTTTGTACTAGGAGGCTGTA| |GGCATAAATTGGTCTGCGCACCAGCACCATGCAACTTTTTCACCTCTGCCTAATCATCTCTTGTTCATGTCCTACTGTTCAAGCCTCCAAGCTGTGCCTT

Chromosome

chr11

Cytoband

q13.1

Reference genome

Start

End

63524960/63757488 (Hg38)

Orient

-

Location type

Intronic

Fragile sites / regions

Target gene

miRNAs that regulate target gene

hsa-mir-155-5p ; hsa-mir-760 ; hsa-mir-484 ; hsa-mir-378a-3p ; hsa-mir-106a-5p ; hsa-mir-17-5p ; hsa-mir-205-5p ; hsa-mir-6515-5p ; hsa-mir-4443 ; hsa-mir-4725-3p ; hsa-mir-6780b-5p ; hsa-mir-4271 ; hsa-mir-6797-5p ; hsa-mir-1249-5p ; hsa-mir-6783-5p ; hsa-mir-671-5p ; hsa-mir-4511 ; hsa-mir-33b-5p ; hsa-mir-33a-5p ; hsa-mir-4684-3p ; hsa-mir-4694-5p ; hsa-mir-367-5p ; hsa-mir-802 ; hsa-mir-522-3p ; hsa-mir-224-3p ; hsa-mir-4694-3p ; hsa-mir-335-3p ; hsa-mir-4775 ; hsa-mir-5692a ; hsa-mir-590-3p ; hsa-mir-6793-3p

Nearest miRNA

hsa-mir-129-2/Upstream/964717; hsa-let-7a-2/Downstream/584361;

Nearest TSS

Nearest CpG islands

None/Target, chr11-CpG: 30/Upstream/75574, chr11-CpG: 188/Downstream/4928

Upstream sequence

cacccaggttgaagtgcagtggcacaagctgaaagctcactgcagccttgacctctgacctcccttgctccaagtgatcctcccaccccagcctcctgag

Downstream sequence

tagctgacactacaggcatgtgccatgccctggcaaattttttattttttatagagatgggggtctcactatgttgcccaggccaggctttaacttctgg