Basic Information
VIS ID
TVIS10012215
Fusion event
HBV-chr12 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
X protein|Polymerase|
Start
1612
Orient
+
Integrated sequence
GACCGACCACGGGGCGCACCTCTCTTTACGCGGACTCCCCGTCTGTGCCTTCTCATCTGCCGGACCGTGTGCACTTCGCTTCACCTCTGCACGTCGCATG| |GAGACCACCGTGAACGCCCACCAAATATTGCCCAAGGTCTTACATAAGAGGACTCTTGGACTCTCAGCAATGTCAACGACCGACCTTGAGGCATACTTCA
Host Sequence
Chromosome
chr12
Cytoband
q12
Reference genome
GRCh37/hg19
Start
42074594/41680792 (Hg38)
End
42074594/41680792 (Hg38)
Orient
+
Location type
Intergenic
Nearest miRNA
hsa-mir-1244-3/Upstream/15806713; hsa-let-7i/Downstream/642908;
Nearest TSS
ENST00000382841/Upstream/171241; ENST00000548210/Downstream/83397;
Nearest CpG islands
None/Target, chr12-CpG: 104/Upstream/107119, chr12-CpG: 92/Downstream/463531
Nearby gene
PDZRN4(-106202) ; GXYLT1(+401054) ;
Upstream sequence
aaattatagatgatgtattattatatgtgcaatttatgggaaagagaggataaaagatcttttgaatatggttagatttacatccatctaaaaacatgtc
Downstream sequence
tgtgttctgcattcaaaatagtggagaagttttaaggtaaaataaaatgatgtttgcatacttcaattttttaatgattccacactttaatagatttttt
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
Curate