Basic Information
VIS ID
TVIS10012222
Fusion event
HBV-chr12 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
X protein|
Start
1799
Orient
-
Integrated sequence
GAGGCATACTTCAAAGACTGTTTGTTTAAAGACTGGGAGGAGTTGGGGGAGGAGATTAGGTTAAAGGTCTTTGTACTAGGAGGCTGTAGGCATAAATTGG| |TCTGCGCACCAGCACCATGCAACTTTTTCACCTCTGCCTAATCATCTCTTGTTCATGTCCTACTGTTCAAGCCTCCAAGCTGTGCCTTGGGTGGCTTTGG
Host Sequence
Chromosome
chr12
Cytoband
q15
Reference genome
GRCh37/hg19
Start
69436755/69042975 (Hg38)
End
69436755/69042975 (Hg38)
Orient
+
Location type
Intergenic
Nearest miRNA
hsa-let-7i/Upstream/2791818; hsa-mir-1178/Downstream/230182;
Nearest TSS
ENST00000382841/Upstream/71405; ENST00000548266/Downstream/169148;
Nearest CpG islands
None/Target, chr12-CpG: 104/Upstream/109223, chr12-CpG: 110/Downstream/196517
Nearby gene
CPM(-79735) ; CPSF6(+196562) ;
Upstream sequence
gaattagtaatgacaagcactgctaccacccctctatcccccatccatcccagacctgacaggacaagaggagaaggtgcttaccagaggcagagtcaga
Downstream sequence
gggccccatggagagggcgcatgacggggcatgtgtggcctttggtggggagatacagccagcctgcagtgactccacagaaagggagctggagagtgaa
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
Curate