Basic Information
VIS ID
TVIS10012223
Fusion event
HBV-chr12 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
precore/core protein|
Start
1839
Orient
+
Integrated sequence
AGTTGGGGGAGGAGATTAGGTTAAAGGTCTTTGTACTAGGAGGCTGTAGGCATAAATTGGTCTGCGCACCAGCACCATGCAACTTTTTCACCTCTGCCTA| |ATCATCTCTTGTTCATGTCCTACTGTTCAAGCCTCCAAGCTGTGCCTTGGGTGGCTTTGGGGCATGGACATCGACCCTTATAAAGAATTTGGAGCTACTG
Host Sequence
Chromosome
chr12
Cytoband
q15
Reference genome
GRCh37/hg19
Start
69436766/69042986 (Hg38)
End
69436766/69042986 (Hg38)
Orient
-
Location type
Intergenic
Nearest miRNA
hsa-let-7i/Upstream/2791829; hsa-mir-1178/Downstream/230171;
Nearest TSS
ENST00000382841/Upstream/71416; ENST00000548266/Downstream/169137;
Nearest CpG islands
None/Target, chr12-CpG: 104/Upstream/109234, chr12-CpG: 110/Downstream/196506
Nearby gene
CPM(-79746) ; CPSF6(+196551) ;
Upstream sequence
gacaagcactgctaccacccctctatcccccatccatcccagacctgacaggacaagaggagaaggtgcttaccagaggcagagtcagagggccccatgg
Downstream sequence
agagggcgcatgacggggcatgtgtggcctttggtggggagatacagccagcctgcagtgactccacagaaagggagctggagagtgaatacaccagtgt
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
Curate