Basic Information
VIS ID
TVIS10012227
Fusion event
HBV-LOC105369902 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
X protein|precore/core protein|
Start
1819
Orient
-
Integrated sequence
TTTGTTTAAAGACTGGGAGGAGTTGGGGGAGGAGATTAGGTTAAAGGTCTTTGTACTAGGAGGCTGTAGGCATAAATTGGTCTGCGCACCAGCACCATGC| |AACTTTTTCACCTCTGCCTAATCATCTCTTGTTCATGTCCTACTGTTCAAGCCTCCAAGCTGTGCCTTGGGTGGCTTTGGGGCATGGACATCGACCCTTA
Host Sequence
Chromosome
chr12
Cytoband
q22
Reference genome
GRCh37/hg19
Start
92762122/92368346 (Hg38)
End
92762122/92368346 (Hg38)
Orient
-
Location type
Intronic
Fragile sites / regions
FRA12B
Target gene
LOC105369902
Nearest miRNA
hsa-let-7i/Upstream/5623197; hsa-mir-1178/Downstream/2193443;
Nearest TSS
ENST00000382841/Upstream/4514; ENST00000508671/Downstream/53185;
Nearest CpG islands
None/Target, chr12-CpG: 104/Upstream/221789, chr12-CpG: 133/Downstream/560220
Nearby gene
BTG1(-222449) ; CLLU1OS(+51748) ;
Upstream sequence
ttgttgttgttgttcttaggacataggtcaactgatttggagaagtattttcctggggcctgaatggtgtgcaccacagaagtgaatgttttaggatttc
Downstream sequence
agtaatgctgtgatggctccgagtgtaagattccaagtcatagaggcccctatgtgtttgctaataaatgtagtgtttctgggtttgctatatgcagggc
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
Curate