Basic Information
VIS ID
TVIS10012232
Fusion event
HBV-LINC00457 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
X protein|precore/core protein|
Start
1827
Orient
-
Integrated sequence
AAGACTGGGAGGAGTTGGGGGAGGAGATTAGGTTAAAGGTCTTTGTACTAGGAGGCTGTAGGCATAAATTGGTCTGCGCACCAGCACCATGCAACTTTTT| |CACCTCTGCCTAATCATCTCTTGTTCATGTCCTACTGTTCAAGCCTCCAAGCTGTGCCTTGGGTGGCTTTGGGGCATGGACATCGACCCTTATAAAGAAT
Host Sequence
Chromosome
chr13
Cytoband
q13.2
Reference genome
GRCh37/hg19
Start
35160386/34586249 (Hg38)
End
35160386/34586249 (Hg38)
Orient
-
Location type
ncRNA_intronic
Fragile sites / regions
FRA13A
Target gene
LINC00457
Nearest miRNA
hsa-mir-2276/Upstream/10423745; hsa-mir-1267/Downstream/5077785;
Nearest TSS
ENST00000623511/Upstream/51899; ENST00000497540/Downstream/54436;
Nearest CpG islands
None/Target, chr13-CpG: 551/Upstream/767893, chr13-CpG: 79/Downstream/355985
Upstream sequence
aaaaagaaggaaagaaagaagagaagaaaagaaaAATGAGTCTTCAATGATCTTTGGAGAGGGCTCAGAGAATGGGCAGAGCCTTGAACGGGGTGTGACT
Downstream sequence
CTGGACTCTTGCTGCCAAGGAGAGAATAGATTGGGGAGATGAGAAGCCGAGGGAGTAGGCTCTCCTGGAGTCCATGCATGACATGCTGGTGGCATGTGGT
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
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