Basic Information
VIS ID
TVIS10012238
Fusion event
HBV-DGLUCY integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
X protein|
Start
1807
Orient
-
Integrated sequence
CTTCAAAGACTGTTTGTTTAAAGACTGGGAGGAGTTGGGGGAGGAGATTAGGTTAAAGGTCTTTGTACTAGGAGGCTGTAGGCATAAATTGGTCTGCGCA| |CCAGCACCATGCAACTTTTTCACCTCTGCCTAATCATCTCTTGTTCATGTCCTACTGTTCAAGCCTCCAAGCTGTGCCTTGGGTGGCTTTGGGGCATGGA
Host Sequence
Chromosome
chr14
Cytoband
q32.11
Reference genome
GRCh37/hg19
Start
91686094/91219750 (Hg38)
End
91686094/91219750 (Hg38)
Orient
+
Location type
Intronic
Target gene
DGLUCY
miRNAs that regulate target gene
hsa-mir-375
Nearest miRNA
hsa-mir-1260a/Upstream/13953460; hsa-mir-1185-1/Downstream/2728476;
Nearest TSS
ENST00000550708/Upstream/3893; ENST00000563574/Downstream/24758;
Nearest CpG islands
None/Target, chr14-CpG: 35/Upstream/158542, chr14-CpG: 87/Downstream/13987
Upstream sequence
CATCACTACCTGGGCACACCCTGCCCACTCTGGCCCTTGGCCCAGGGGCACCTTAAAGTGAGGGAGAGGCCCTTGGGTTGTACTTGAGGGCAAGCATTCC
Downstream sequence
TAAGACGTCATCAAGGGCCAAGAGCCACTTGATGACACTTTACAGGGGTACCTGCAAGGTCTGATAAGGAGGACTTGGAGCTCAGGAGGTGGAGAACTTG
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
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