Basic Information
VIS ID
TVIS10012239
Fusion event
HBV-DGLUCY integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
precore/core protein|Core and e antigen|
Start
1986
Orient
+
Integrated sequence
TGGGTGGCTTTGGGGCATGGACATCGACCCTTATAAAGAATTTGGAGCTACTGTGGAGTTACTCTCGTTTTTGCCTTCTGACTTCTTTCCTTCAGTACGA| |GATCTTCTAGATACCGCCTCAGCTCTGTATCGGGAAGCCTTAGAGTCTCCTGAGCATTGTTCACCTCACCATACTGCACTCAGGCAAGCAATTCTTTGCT
Host Sequence
Chromosome
chr14
Cytoband
q32.11
Reference genome
GRCh37/hg19
Start
91686124/91219780 (Hg38)
End
91686124/91219780 (Hg38)
Orient
-
Location type
Intronic
Target gene
DGLUCY
miRNAs that regulate target gene
hsa-mir-375
Nearest miRNA
hsa-mir-1260a/Upstream/13953490; hsa-mir-1185-1/Downstream/2728446;
Nearest TSS
ENST00000550708/Upstream/3923; ENST00000563574/Downstream/24728;
Nearest CpG islands
None/Target, chr14-CpG: 35/Upstream/158572, chr14-CpG: 87/Downstream/13957
Upstream sequence
TGGCCCTTGGCCCAGGGGCACCTTAAAGTGAGGGAGAGGCCCTTGGGTTGTACTTGAGGGCAAGCATTCCTAAGACGTCATCAAGGGCCAAGAGCCACTT
Downstream sequence
GATGACACTTTACAGGGGTACCTGCAAGGTCTGATAAGGAGGACTTGGAGCTCAGGAGGTGGAGAACTTGGTCTTCCTCAGCTTGGGGGCCAAGGTGCTG
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
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