Basic Information
VIS ID
TVIS10012242
Fusion event
HBV-chr15 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
precore/core protein|
Start
1890
Orient
+
Integrated sequence
ATAAATTGGTCTGCGCACCAGCACCATGCAACTTTTTCACCTCTGCCTAATCATCTCTTGTTCATGTCCTACTGTTCAAGCCTCCAAGCTGTGCCTTGGG| |TGGCTTTGGGGCATGGACATCGACCCTTATAAAGAATTTGGAGCTACTGTGGAGTTACTCTCGTTTTTGCCTTCTGACTTCTTTCCTTCAGTACGAGATC
Host Sequence
Chromosome
chr15
Cytoband
q14
Reference genome
GRCh37/hg19
Start
39412325/39120124 (Hg38)
End
39412325/39120124 (Hg38)
Orient
-
Location type
Intergenic
Nearest miRNA
hsa-mir-1233-1/Upstream/2147223; hsa-mir-10393/Downstream/2571461;
Nearest TSS
ENST00000557528/Upstream/1411; ENST00000560259/Downstream/47615;
Nearest CpG islands
None/Target, chr15-CpG: 55/Upstream/554667, chr15-CpG: 109/Downstream/460202
Nearby gene
LINC02694(-420086) ; C15orf54(+130560) ;
Upstream sequence
aaaataagcagtggggaaaggagttcatattcaataaatggtgctgagatagctggctagccatgtgcagaagaatgaaactggatccctacctttcatc
Downstream sequence
atatacaaaaattaagtcaagatgaattaaagatttaaatataagacatcaaactataagaatcctagaagaacgcccaataaacaccattctggaaact
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
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