Basic Information
VIS ID
TVIS10012243
Fusion event
HBV-chr15 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
X protein|precore/core protein|
Start
1822
Orient
-
Integrated sequence
GTTTAAAGACTGGGAGGAGTTGGGGGAGGAGATTAGGTTAAAGGTCTTTGTACTAGGAGGCTGTAGGCATAAATTGGTCTGCGCACCAGCACCATGCAAC| |TTTTTCACCTCTGCCTAATCATCTCTTGTTCATGTCCTACTGTTCAAGCCTCCAAGCTGTGCCTTGGGTGGCTTTGGGGCATGGACATCGACCCTTATAA
Host Sequence
Chromosome
chr15
Cytoband
q14
Reference genome
GRCh37/hg19
Start
39849424/39557223 (Hg38)
End
39849424/39557223 (Hg38)
Orient
+
Location type
Intergenic
Nearest miRNA
hsa-mir-1233-1/Upstream/2584322; hsa-mir-10393/Downstream/2134362;
Nearest TSS
ENST00000557528/Upstream/37369; ENST00000397591/Downstream/23856;
Nearest CpG islands
None/Target, chr15-CpG: 55/Upstream/991766, chr15-CpG: 109/Downstream/23103
Nearby gene
C15orf54(-302376) ; THBS1(+23856) ;
Nearest cancer related gene
THBS1(TSG, +23856) ;
Upstream sequence
TTTTACTATAGCTACTGCCCCCAAAGGCACCTTTGGATGCCATCTTTGGATTTCTCACGATTTTTCAATATGTAGAACATAGTAGATTCTCACACAATAT
Downstream sequence
CTGCAGAATGAAAAAATAAAAGTGTGCATGCAAAGGGGTGGCTGGGTCACTGTAGTCCACCCCAGAGAAGACGGGAAAATGCATTTTGCTAAGGCACACA
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
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