Basic Information
VIS ID
TVIS10012244
Fusion event
HBV-CCDC32 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
S protein|Polymerase|large S protein|middle S protein|
Start
718
Orient
+
Integrated sequence
TCCTGGGCTTTCGGAAAATTCCTATGGGAGTGGGCCTCAGCCCGTTTCTCCTGGCTCAGTTTACTAGTGCCATTTGTTCAGTGGTTCGTAGGGCTTTCCC| |CCACTGTTTGGCTTTCAGTTATATGGATGATGTGGTATTGGGGGCCAAGTCTGTACAGCATCTTGAGTCCCTTTTTACCGCTGTTACCAATTTTCTTTTG
Host Sequence
Chromosome
chr15
Cytoband
q15.1
Reference genome
GRCh37/hg19
Start
40833012/40540813 (Hg38)
End
40833012/40540813 (Hg38)
Orient
+
Location type
Intronic
Target gene
CCDC32
miRNAs that regulate target gene
hsa-mir-193b-3p ; hsa-mir-375 ; hsa-mir-24-3p ; hsa-mir-574-5p ; hsa-mir-6867-5p ; hsa-mir-1307-3p ; hsa-mir-423-3p
Nearest miRNA
hsa-mir-1233-1/Upstream/3567912; hsa-mir-10393/Downstream/1150772;
Nearest TSS
ENST00000557528/Upstream/32789; ENST00000616318/Downstream/21990;
Nearest CpG islands
None/Target, chr15-CpG: 55/Upstream/28817, chr15-CpG: 60/Downstream/28399
Nearby gene
MRPL42P5(-8263) ; CCDC32(+12286) ;
Upstream sequence
CTCTGGGGCCGGGCCAGTCTCTCATCTATCCTAACCTTGACCACAGTGTGAAAGGACAGTAGAGTCAGTGCCCCTAATGTCACCATGTTCCAAGCTCACA
Downstream sequence
TATGAGTGTTGAACAGGTGCCAGCCTGGAGCGTCCATTGCCCTGGTGCCCTCAGTCCAGAGAGCCCAGTGAGAAGCTGGGCCAAGAAGGAAGACTTGAAC
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
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