Expression analysis of TCGA samples
Basic Information
VIS ID
TVIS10012246
Fusion event
HBV-MEGF11 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
Virus Sequence
Virus name
HBV
Reference genome
Region type
precore/core protein|
Start
1866
Orient
+
Integrated sequence
TCTTTGTACTAGGAGGCTGTAGGCATAAATTGGTCTGCGCACCAGCACCATGCAACTTTTTCACCTCTGCCTAATCATCTCTTGTTCATGTCCTACTGTT| |CAAGCCTCCAAGCTGTGCCTTGGGTGGCTTTGGGGCATGGACATCGACCCTTATAAAGAATTTGGAGCTACTGTGGAGTTACTCTCGTTTTTGCCTTCTG
Host Sequence
Chromosome
chr15
Cytoband
q22.31
Reference genome
Start
End
66245084/65952746 (Hg38)
Orient
+
Location type
Intronic
Fragile sites / regions
Target gene
miRNAs that regulate target gene
Nearest miRNA
hsa-mir-10393/Upstream/233414; hsa-mir-11181/Downstream/87487;
Nearest CpG islands
None/Target, chr15-CpG: 55/Upstream/82491, chr15-CpG: 30/Downstream/29450
Upstream sequence
CTGAAACGATGCCGTTTCCACTTGTAAGCACTCCCACTGGAATGACTAGCTCCCACACCACTGTTTCCGATgggcagggaatttcattcccattttatag
Downstream sequence
atgagaaatagaaacccagaaagttagcagagctaaagctacaaactcatttcttgttttctggtccagggctctttgcccccactgggcagccacagtg
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.