Basic Information
VIS ID
TVIS10012250
Fusion event
HBV-NPIPB11 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
Polymerase|
Start
2795
Orient
+
Integrated sequence
AAACCTTATTATCCAGAACATCTAGTTAATCATTACTTCCAAACTAGACACTATTTACACACTCTATGGAAGGCGGGTATATTATATAAGAGAGAAACAA| |CACATAGCGCCTCATTTTGTGGGTCACCATATTCTTGGGAACAAGATCTACAGCATGGGGCAGAATCTTTCCACCAGCAATCCTCTGGGATTCTTTCCCG
Host Sequence
Chromosome
chr16
Cytoband
p11.2
Reference genome
GRCh37/hg19
Start
29405880/29394559 (Hg38)
End
29405880/29394559 (Hg38)
Orient
+
Location type
Intronic
Target gene
NPIPB11
Nearest miRNA
hsa-mir-1225/Upstream/435898; hsa-mir-11401/Downstream/204620;
Nearest TSS
ENST00000527434/Upstream/122339; ENST00000567248/Downstream/3137;
Nearest CpG islands
None/Target, chr16-CpG: 29/Upstream/95469, chr16-CpG: 146/Downstream/59473
Nearby gene
SNX29P2(-29500) ; LOC606724(+54786) ;
Upstream sequence
cgctccactcagtcgcccaggctggagtgaagtggtgcaatcttggctcactacaacctccagctcctgggctcaagccattctcctgcctcagcctccc
Downstream sequence
gagtagctgagattacaggtctctgccaccatgcccgactcatttttgtatttttagtagagatgaggtttcaccatgttggccagtctggccttgaact
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
Curate