Basic Information
VIS ID
TVIS10012251
Fusion event
HBV-NPIPB11 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
X protein|Polymerase|
Start
1485
Orient
-
Integrated sequence
GGCTGTGCTGCCAACTGGATCCTGCGCGGGACGTCCTTTGTTTACGTCCCGTCGGCGCTGAATCCTGCGGACGACCCTTCTCGGGGTCGCTTGGGACTCT| |CTCGTCCCCTTCTCCGTCTGCCGTTCCGACCGACCACGGGGCGCACCTCTCTTTACGCGGACTCCCCGTCTGTGCCTTCTCATCTGCCGGACCGTGTGCA
Host Sequence
Chromosome
chr16
Cytoband
p11.2
Reference genome
GRCh37/hg19
Start
29405953/29394632 (Hg38)
End
29405953/29394632 (Hg38)
Orient
-
Location type
Intronic
Target gene
NPIPB11
Nearest miRNA
hsa-mir-1225/Upstream/435971; hsa-mir-11401/Downstream/204547;
Nearest TSS
ENST00000527434/Upstream/122412; ENST00000567248/Downstream/3064;
Nearest CpG islands
None/Target, chr16-CpG: 29/Upstream/95542, chr16-CpG: 146/Downstream/59400
Nearby gene
SNX29P2(-29573) ; LOC606724(+54713) ;
Upstream sequence
caagccattctcctgcctcagcctcccgagtagctgagattacaggtctctgccaccatgcccgactcatttttgtatttttagtagagatgaggtttca
Downstream sequence
ccatgttggccagtctggccttgaactcctgacaggcgatctgcctgcctcagcctcccaaagtgctgggattacaggtgtgagccaccgtgcccagccA
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
Curate