VISDB Viral Integration Site DataBase

VIS ID

TVIS10012254

Fusion event

HBV-MMP15 integration

Validated

No

Detection method

NGS

Data source

Curated

Sample type

Disease

Hepatocellular carcinoma (HCC)

Quality evaluation

Normal

Reported year

2018

PubMed ID

Virus name

HBV

Reference genome

Region type

X protein|precore/core protein|

Start

1815

Orient

-

Integrated sequence

ACTGTTTGTTTAAAGACTGGGAGGAGTTGGGGGAGGAGATTAGGTTAAAGGTCTTTGTACTAGGAGGCTGTAGGCATAAATTGGTCTGCGCACCAGCACC| |ATGCAACTTTTTCACCTCTGCCTAATCATCTCTTGTTCATGTCCTACTGTTCAAGCCTCCAAGCTGTGCCTTGGGTGGCTTTGGGGCATGGACATCGACC

Chromosome

chr16

Cytoband

q21

Reference genome

Start

End

58070018/58036114 (Hg38)

Orient

+

Location type

Intronic

Target gene

miRNAs that regulate target gene

hsa-mir-29b-3p ; hsa-mir-29c-3p ; hsa-mir-8057 ; hsa-mir-3915 ; hsa-mir-760 ; hsa-mir-6822-3p ; hsa-mir-3928-3p ; hsa-mir-3202 ; hsa-mir-7162-3p ; hsa-mir-4649-3p ; hsa-mir-4653-5p ; hsa-mir-3921 ; hsa-mir-3158-3p ; hsa-mir-6876-5p ; hsa-mir-4476

Nearest miRNA

hsa-mir-1225/Upstream/263762; hsa-mir-11401/Downstream/9166207;

Nearest TSS

Nearest CpG islands

None/Target, chr16-CpG: 29/Upstream/8541, chr16-CpG: 18/Downstream/3798

Upstream sequence

GCCGGCCAATATGGCTGTCAGCCTAAAGCAACCACCGTGTCCAGCTACTGCCCTGCTGCCTGGGCCCTCGGGGTGCAGCCCTCACCTCCCAGAGCACTCA

Downstream sequence

GAGTGCCAGCCTTAAGGGCTTCTCACTCTGGAGACCCCCAGAGACCCAGACAAGTCAGACACAGACACTTGCAGTGTCCAAGGTCCAGGGCAGCCCCTGG