Basic Information
VIS ID
TVIS10012257
Fusion event
HBV-LOC102724084 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
precore/core protein|Core and e antigen|
Start
2192
Orient
+
Integrated sequence
AACTAATGACTCTAGCTACCTGGGTGGGTGTTAATTTGGAAGATCCAGCGTCTAGAGACCTAGTAGTCAGTTATGTCAACACTAATATGGGCCTAAAGTT| |CAGGCAACTCTTGTGGTTTCACATTTCTTGTCTCACTTTTGGAAGAGAAACAGTTATAGAGTATTTGGTGTCTTTCGGAGTGTGGATTCGCACTCCTCCA
Host Sequence
Chromosome
chr16
Cytoband
q23.2
Reference genome
GRCh37/hg19
Start
80466818/80432921 (Hg38)
End
80466818/80432921 (Hg38)
Orient
+
Location type
Intronic
Fragile sites / regions
FRA16D
Target gene
LOC102724084
Nearest miRNA
hsa-mir-1225/Upstream/3563902; hsa-mir-11401/Downstream/952097;
Nearest TSS
ENST00000527434/Upstream/253792; ENST00000338542/Downstream/107813;
Nearest CpG islands
None/Target, chr16-CpG: 29/Upstream/831281, chr16-CpG: 42/Downstream/107923
Nearby gene
MAF(-832196) ; DYNLRB2(+108036) ;
Upstream sequence
tgcatcaaaacatctcatgtaccctgtgaatatatacacttactatgtacccacagaaattaaaCTTTTATTAAAAATGAAATATGAGCCAAAAGAACAA
Downstream sequence
GACTAGTACCTATATATTTATCAAAGACAACAGAAAAATAAAATTTTCAAACTTTCTCTTCCCTATGTTTACTGAGATGATTTAGTTTCTGAGTAGTTTA
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
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