Basic Information
VIS ID
TVIS10012258
Fusion event
HBV-chr16 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
Polymerase|
Start
2667
Orient
+
Integrated sequence
ACATTATCAAAAAATGTGAACAGTTTGTAGGCCCACTCACAGTTAATGAGAAAAGAAGATTGCAATTGATTATGCCTGCCAGGTTTTATCCAAAGGTTAC| |CAAATATTTACCATTGGATAAGGGTATTAAACCTTATTATCCAGAACATCTAGTTAATCATTACTTCCAAACTAGACACTATTTACACACTCTATGGAAG
Host Sequence
Chromosome
chr16
Cytoband
q23.3
Reference genome
GRCh37/hg19
Start
82007252/81973647 (Hg38)
End
82007252/81973647 (Hg38)
Orient
+
Location type
Intergenic
Nearest miRNA
hsa-mir-1225/Upstream/362239; hsa-mir-11401/Downstream/715284;
Nearest TSS
ENST00000527434/Upstream/35019; ENST00000614642/Downstream/14301;
Nearest CpG islands
None/Target, chr16-CpG: 29/Upstream/193690, chr16-CpG: 35/Downstream/37634
Nearby gene
PLCG2(-15353) ; SDR42E1(+23999) ;
Upstream sequence
aggcattcagagcacctccttgcctgaatgagtagtctgagccagcccacccttcctgtgtagagacgatggtaaagcgaggacctctctgtcccatgcc
Downstream sequence
caggcatatctctaggcagctgaagcacccactctcctgaattaggaatttaggctgacccctgatctgtacagataacttggggctgaggaggttttcc
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
Curate