Basic Information
VIS ID
TVIS10012264
Fusion event
HBV-chr18 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
Polymerase|
Start
1029
Orient
-
Integrated sequence
CAAAAAATCAAAGAATGTTTTAGAAAACTTCCTATTAACAGGCCTATTGATTGGAAAGTATGTCAACGAATTGTGGGTCTTTTGGGTTTTGCTGCCCCTT| |TTACACAATGTGGTTATCCTGCGTTGATGCCTTTGTATGCATGTATTCAATCTAAGCAGGCTTTCACTTTCTCGCCAACTTACAAGGCCTTTCTGTGTAA
Host Sequence
Chromosome
chr18
Cytoband
q22.1
Reference genome
GRCh37/hg19
Start
64326464/66659227 (Hg38)
End
64326464/66659227 (Hg38)
Orient
+
Location type
Intergenic
Nearest miRNA
hsa-mir-1-2/Upstream/8208069; hsa-mir-5011/Downstream/422357;
Nearest TSS
ENST00000575820/Upstream/55089; ENST00000581951/Downstream/825739;
Nearest CpG islands
None/Target, chr18-CpG: 67/Upstream/907823, chr18-CpG: 83/Downstream/856773
Nearby gene
CDH19(-55248) ; MIR5011(+422357) ;
Upstream sequence
gaagttcttaaactaagaattacatttctctaatagatatgggacaattccagttattcattttatcagttgattttgatagcttgtgttactcaaagag
Downstream sequence
taagtgtttaatttattggcatgcagcttctcatatttcctcACTGTTAAAAGGCCAATATAATATTTCCTTCAAAGGCTAAGATAAATTTGTAAATTAA
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
Curate