Basic Information
VIS ID
TVIS10012273
Fusion event
HBV-MIR548N integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
X protein|precore/core protein|
Start
1814
Orient
-
Integrated sequence
GACTGTTTGTTTAAAGACTGGGAGGAGTTGGGGGAGGAGATTAGGTTAAAGGTCTTTGTACTAGGAGGCTGTAGGCATAAATTGGTCTGCGCACCAGCAC| |CATGCAACTTTTTCACCTCTGCCTAATCATCTCTTGTTCATGTCCTACTGTTCAAGCCTCCAAGCTGTGCCTTGGGTGGCTTTGGGGCATGGACATCGAC
Host Sequence
Chromosome
chr2
Cytoband
q31.2
Reference genome
GRCh37/hg19
Start
179509514/178644787 (Hg38)
End
179509514/178644787 (Hg38)
Orient
+
Location type
ncRNA_intronic
Fragile sites / regions
FRA2G
Target gene
MIR548N
Nearest miRNA
hsa-mir-10b/Upstream/1330905; hsa-mir-1244-1/Downstream/1216049;
Nearest TSS
ENST00000437798/Upstream/70; ENST00000590024/Downstream/6729;
Nearest CpG islands
None/Target, chr2-CpG: 135/Upstream/163757, chr2-CpG: 112/Downstream/619104
Upstream sequence
AAGAATCAAAACCAAGCTTTGCTTATAACCAGAAAGCATTAATAACAGCCAAGAACAGCCTTCAAAGAACATACAAGCAGCATTCGAACCATGAAAACAG
Downstream sequence
ACTGCAGTTTTACTCCAAAGTTCAGTAGTTAATTAAAGACCAGCAGAAAAAGAAGACAATTTTTGTTATTGGCAGGAGGAAGAAATTTTCCTTTAAGCAT
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
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