Basic Information
VIS ID
TVIS10012275
Fusion event
HBV-chr2 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
Polymerase|large S protein|
Start
2850
Orient
-
Integrated sequence
TACACACTCTATGGAAGGCGGGTATATTATATAAGAGAGAAACAACACATAGCGCCTCATTTTGTGGGTCACCATATTCTTGGGAACAAGATCTACAGCA| |TGGGGCAGAATCTTTCCACCAGCAATCCTCTGGGATTCTTTCCCGACCACCAGTTGGATCCAGCCTTCAGAGCAAACACCGCAAATCCAGATTGGGACTT
Host Sequence
Chromosome
chr2
Cytoband
q32.1
Reference genome
GRCh37/hg19
Start
184735555/183870828 (Hg38)
End
184735555/183870828 (Hg38)
Orient
+
Location type
Intergenic
Nearest miRNA
hsa-mir-10b/Upstream/2565176; hsa-mir-1244-1/Downstream/508147;
Nearest TSS
ENST00000437798/Upstream/656509; ENST00000441026/Downstream/33701;
Nearest CpG islands
None/Target, chr2-CpG: 135/Upstream/609973, chr2-CpG: 72/Downstream/727291
Nearby gene
NUP35(-709147) ; ZNF804A(+727538) ;
Upstream sequence
GCCATCTCATATACTGTGTGTTCATTACATGCCAGACATACTATTATGGTCCTGTATTCAAAGTTGGACTGTCtgctatggtatgaatttttgtgttcac
Downstream sequence
ccctaaatgtatatgttgaaatctcattcctagtgggataaggaggtgcggtctttgggaggtgattaggttatgaaagcagagcgctcatgaattacat
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
Curate