Basic Information
VIS ID
TVIS10012276
Fusion event
HBV-chr2 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
Polymerase|
Start
2797
Orient
+
Integrated sequence
ACCTTATTATCCAGAACATCTAGTTAATCATTACTTCCAAACTAGACACTATTTACACACTCTATGGAAGGCGGGTATATTATATAAGAGAGAAACAACA| |CATAGCGCCTCATTTTGTGGGTCACCATATTCTTGGGAACAAGATCTACAGCATGGGGCAGAATCTTTCCACCAGCAATCCTCTGGGATTCTTTCCCGAC
Host Sequence
Chromosome
chr2
Cytoband
q32.1
Reference genome
GRCh37/hg19
Start
184735599/183870872 (Hg38)
End
184735599/183870872 (Hg38)
Orient
-
Location type
Intergenic
Nearest miRNA
hsa-mir-10b/Upstream/2565220; hsa-mir-1244-1/Downstream/508103;
Nearest TSS
ENST00000437798/Upstream/656553; ENST00000441026/Downstream/33657;
Nearest CpG islands
None/Target, chr2-CpG: 135/Upstream/610017, chr2-CpG: 72/Downstream/727247
Nearby gene
NUP35(-709191) ; ZNF804A(+727494) ;
Upstream sequence
TATGGTCCTGTATTCAAAGTTGGACTGTCtgctatggtatgaatttttgtgttcacccctaaatgtatatgttgaaatctcattcctagtgggataagga
Downstream sequence
ggtgcggtctttgggaggtgattaggttatgaaagcagagcgctcatgaattacattagtgcccttataaaacaagccccaaggagttcctttgcccttt
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
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