Basic Information
VIS ID
TVIS10012278
Fusion event
HBV-LOC107985978 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
X protein|Polymerase|
Start
1461
Orient
-
Integrated sequence
TATACATCGTTTCCATGGCTGCTAGGCTGTGCTGCCAACTGGATCCTGCGCGGGACGTCCTTTGTTTACGTCCCGTCGGCGCTGAATCCTGCGGACGACC| |CTTCTCGGGGTCGCTTGGGACTCTCTCGTCCCCTTCTCCGTCTGCCGTTCCGACCGACCACGGGGCGCACCTCTCTTTACGCGGACTCCCCGTCTGTGCC
Host Sequence
Chromosome
chr2
Cytoband
q34
Reference genome
GRCh37/hg19
Start
211947446/211082722 (Hg38)
End
211947446/211082722 (Hg38)
Orient
-
Location type
Intronic
Target gene
LOC107985978
Nearest miRNA
hsa-mir-10b/Upstream/3327841; hsa-mir-1244-1/Downstream/1343541;
Nearest TSS
ENST00000437798/Upstream/411107; ENST00000434559/Downstream/582632;
Nearest CpG islands
None/Target, chr2-CpG: 135/Upstream/605910, chr2-CpG: 86/Downstream/1454734
Nearby gene
CPS1(-403615) ; ERBB4(+292996) ;
Upstream sequence
tagattaaaatagacatgcaacaaacctattgtcatataaatccagagaattcaagacaagctccctagaagtttatagaaagaaaaaaataatagttac
Downstream sequence
ttacaaaagagtaagaatcataatatctttgaacccctcaacaagaacagtggaaactagaaagtggtggaggaaggctctcaatattctgaggggaagt
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
Curate