VISDB Viral Integration Site DataBase

VIS ID

TVIS10012280

Fusion event

HBV-IKZF2 integration

Validated

No

Detection method

NGS

Data source

Curated

Sample type

Disease

Hepatocellular carcinoma (HCC)

Quality evaluation

Normal

Reported year

2018

PubMed ID

Virus name

HBV

Reference genome

Region type

precore/core protein|

Start

1870

Orient

+

Integrated sequence

TGTACTAGGAGGCTGTAGGCATAAATTGGTCTGCGCACCAGCACCATGCAACTTTTTCACCTCTGCCTAATCATCTCTTGTTCATGTCCTACTGTTCAAG| |CCTCCAAGCTGTGCCTTGGGTGGCTTTGGGGCATGGACATCGACCCTTATAAAGAATTTGGAGCTACTGTGGAGTTACTCTCGTTTTTGCCTTCTGACTT

Chromosome

chr2

Cytoband

q34

Reference genome

Start

End

213963560/213098836 (Hg38)

Orient

-

Location type

Intronic

Target gene

miRNAs that regulate target gene

hsa-mir-130b-5p ; hsa-mir-125b-5p ; hsa-mir-374a-5p ; hsa-mir-627-3p ; hsa-mir-633 ; hsa-mir-450b-5p ; hsa-mir-6805-5p ; hsa-mir-876-5p ; hsa-mir-1290 ; hsa-mir-3167 ; hsa-mir-5004-3p ; hsa-mir-506-5p ; hsa-mir-1260a ; hsa-mir-1260b ; hsa-mir-6083 ; hsa-mir-5096 ; hsa-mir-3926 ; hsa-mir-4650-5p ; hsa-mir-1972 ; hsa-mir-10b-3p ; hsa-mir-6869-5p ; hsa-mir-496 ; hsa-mir-942-5p ; hsa-mir-5006-3p ; hsa-mir-4755-5p ; hsa-mir-8061 ; hsa-mir-4760-5p ; hsa-mir-211-5p ; hsa-mir-204-5p ; hsa-mir-623 ; hsa-mir-376a-5p ; hsa-mir-3938 ; hsa-mir-6844 ; hsa-mir-524-5p ; hsa-mir-520d-5p ; hsa-mir-5588-3p ; hsa-mir-6832-3p ; hsa-mir-3156-3p ; hsa-mir-188-3p ; hsa-mir-1236-3p ; hsa-mir-877-3p ; hsa-mir-4301 ; hsa-mir-1306-5p ; hsa-mir-7850-5p ; hsa-mir-1277-5p ; hsa-mir-190a-3p ; hsa-mir-5011-5p ; hsa-mir-32-5p ; hsa-mir-92a-3p ; hsa-mir-92b-3p ; hsa-mir-30e-5p ; hsa-mir-30d-5p ; hsa-mir-30b-5p ; hsa-mir-30c-5p ; hsa-mir-30a-5p

Nearest miRNA

hsa-mir-10b/Upstream/172500; hsa-mir-1244-1/Downstream/659231;

Nearest TSS

Nearest CpG islands

None/Target, chr2-CpG: 135/Upstream/265510, chr2-CpG: 39/Downstream/53190

Nearest cancer related gene

IKZF2(TSG, No orient, 0)

Upstream sequence

TCTCACTCTGTCCCGGTTAAAACCTGTTTGTCTGGGGATTGGCTCAGCTGCTCCAGTTCCAGCTTCCCGGCCTTCCAAGGTGCTGACGTGACCTCAGTTG

Downstream sequence

TCATTCTGCTGGAGCTAGATCCAACTAACAAAATCCAACACATGCAGGCACTTGTTTCTCCATTATCCAGTGCCTTCAAGGGCAGCAGAGAATCAGGGAG