Basic Information
VIS ID
TVIS10012288
Fusion event
HBV-chr2 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
Polymerase|
Start
2469
Orient
-
Integrated sequence
TAGAAGAAGAACTCCCTCGCCTCGCAGACGAAGGTCTCAATCGCCGCGTCGCAGAAGATCTCAATCTCGGGAATCTCAATGTTAGTATTCCTTGGACTCA| |TAAGGTGGGGAACTTTACTGGGCTTTATTCTTCTACTGTACCTGTCTTTAATCCTCATTGGAAAACACCATCTTTTCCTAATATACATTTACACCAAGAC
Host Sequence
Chromosome
chr2
Cytoband
q11.2
Reference genome
GRCh37/hg19
Start
97658241/96992504 (Hg38)
End
97658241/96992504 (Hg38)
Orient
-
Location type
Intergenic
Fragile sites / regions
FRA2S ; FRA2A
Nearest miRNA
hsa-mir-1285-2/Upstream/194151; hsa-mir-10b/Downstream/4316946;
Nearest TSS
ENST00000437798/Upstream/5912; ENST00000605129/Downstream/54084;
Nearest CpG islands
None/Target, chr2-CpG: 135/Upstream/5800, chr2-CpG: 50/Downstream/101943
Nearby gene
FAM178B(-5940) ; FAHD2B(+91082) ;
Upstream sequence
CCAGGCCCTGCTGTCCCTGGTGTCAAGCGTACCTTGATGGCCAGCTGACAGTCTTCCCAAAAGTGGTTTTACCAGTTTTCCCACAAGGAGAGGTACCACT
Downstream sequence
TCTAGTCCCTGTCTTTACAGTTATTGGTGAGTGACCAATGTGGAATGAGGCAGATAAACTTCTTTTCCTCATTTAGCTGAGGGAGTCTTTTCCTGGGCTT
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
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