Basic Information
VIS ID
TVIS10012293
Fusion event
HBV-chr20 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
precore/core protein|Core and e antigen|Polymerase|
Start
2338
Orient
+
Integrated sequence
GAAACAGTTATAGAGTATTTGGTGTCTTTCGGAGTGTGGATTCGCACTCCTCCAGCTTATAGACCACCAAATGCCCCTATCCTATCAACACTTCCGGAGA| |CTACTGTTGTTAGACGACGAGGCAGGTCCCCTAGAAGAAGAACTCCCTCGCCTCGCAGACGAAGGTCTCAATCGCCGCGTCGCAGAAGATCTCAATCTCG
Host Sequence
Chromosome
chr20
Cytoband
q13.2
Reference genome
GRCh37/hg19
Start
52923428/54306889 (Hg38)
End
52923428/54306889 (Hg38)
Orient
-
Location type
Intergenic
Nearest miRNA
hsa-mir-103a-2/Upstream/238404; hsa-mir-1-1/Downstream/3014613;
Nearest TSS
ENST00000382410/Upstream/98461; ENST00000491469/Downstream/168708;
Nearest CpG islands
None/Target, chr20-CpG: 39/Upstream/98380, chr20-CpG: 96/Downstream/168305
Nearby gene
PFDN4(-86936) ; DOK5(+168838) ;
Upstream sequence
cctttaaagtgaagtcaactgattggagatgttaactccttcaagtaccttcacaggaacacttagattagtgtttctaatgatagcctagctgggttga
Downstream sequence
cattataaaactaaccatTGAAGTATCCTTTGGTTGTAAATTGTAGCACAGCTAATCAAACTAACTTCCTAATATTGGCTAAGGCCGactgagggttact
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
Curate