Basic Information
VIS ID
TVIS10012294
Fusion event
HBV-LOC105372745 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
X protein|
Start
1799
Orient
-
Integrated sequence
GAGGCATACTTCAAAGACTGTTTGTTTAAAGACTGGGAGGAGTTGGGGGAGGAGATTAGGTTAAAGGTCTTTGTACTAGGAGGCTGTAGGCATAAATTGG| |TCTGCGCACCAGCACCATGCAACTTTTTCACCTCTGCCTAATCATCTCTTGTTCATGTCCTACTGTTCAAGCCTCCAAGCTGTGCCTTGGGTGGCTTTGG
Host Sequence
Chromosome
chr21
Cytoband
q21.1
Reference genome
GRCh37/hg19
Start
21301029/19928715 (Hg38)
End
21301029/19928715 (Hg38)
Orient
+
Location type
Intronic
Target gene
LOC105372745
Nearest miRNA
hsa-let-7c/Upstream/1242551; hsa-mir-155/Downstream/3150569;
Nearest TSS
ENST00000624081/Upstream/28960; ENST00000486367/Downstream/330105;
Nearest CpG islands
None/Target, chr21-CpG: 261/Upstream/1683158, chr21-CpG: 89/Downstream/1068390
Nearby gene
TMPRSS15(-1525059) ; LINC00320(+813884) ;
Upstream sequence
ggagtgcagtggctcgatctccgctcactgcaagctccgcctcccgggttcacgccattctcctgcctcagcctcccgagtagctgggactgcgggcgcc
Downstream sequence
caccaccacgcccagctaattttgtgtatttttagtagagatggggtttcaccgtgttggccaggatagtctccatctcctgacctcgtgatccacccgc
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
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