VISDB Viral Integration Site DataBase

VIS ID

TVIS10012296

Fusion event

HBV-MYLK integration

Validated

No

Detection method

NGS

Data source

Curated

Sample type

Disease

Hepatocellular carcinoma (HCC)

Quality evaluation

Normal

Reported year

2018

PubMed ID

Virus name

HBV

Reference genome

Region type

X protein|precore/core protein|

Start

1816

Orient

-

Integrated sequence

CTGTTTGTTTAAAGACTGGGAGGAGTTGGGGGAGGAGATTAGGTTAAAGGTCTTTGTACTAGGAGGCTGTAGGCATAAATTGGTCTGCGCACCAGCACCA| |TGCAACTTTTTCACCTCTGCCTAATCATCTCTTGTTCATGTCCTACTGTTCAAGCCTCCAAGCTGTGCCTTGGGTGGCTTTGGGGCATGGACATCGACCC

Chromosome

chr3

Cytoband

q21.1

Reference genome

Start

End

123449821/123730974 (Hg38)

Orient

-

Location type

Intronic

Target gene

miRNAs that regulate target gene

hsa-mir-193b-3p ; hsa-mir-155-5p ; hsa-mir-9-5p ; hsa-mir-4276 ; hsa-mir-3682-3p ; hsa-mir-5190 ; hsa-mir-4717-3p ; hsa-mir-1272 ; hsa-mir-5094 ; hsa-mir-513b-3p ; hsa-mir-136-3p ; hsa-mir-587 ; hsa-mir-6077 ; hsa-mir-5581-3p ; hsa-mir-7-5p ; hsa-mir-490-5p ; hsa-mir-4328 ; hsa-mir-5047 ; hsa-mir-1301-3p ; hsa-mir-7156-3p ; hsa-mir-4684-3p ; hsa-mir-4252 ; hsa-mir-7153-5p ; hsa-mir-146b-5p ; hsa-mir-146a-5p ; hsa-mir-589-5p ; hsa-mir-4251 ; hsa-mir-181a-2-3p ; hsa-mir-4691-3p ; hsa-mir-8063 ; hsa-mir-18a-5p ; hsa-mir-200c-3p

Nearest miRNA

hsa-let-7g/Upstream/569095; hsa-mir-12124/Downstream/401955;

Nearest TSS

Nearest CpG islands

None/Target, chr3-CpG: 148/Upstream/145603, chr3-CpG: 34/Downstream/153335

Upstream sequence

catgagatcaactttttaagatcccacacgtgagtgacagaatgtggtatttgtcttttttcacttttctaacctagttatttcacttaacatagcaatc

Downstream sequence

ATTACCCCATGACGCGAACAGGCTAAAAATAGTCTTCTGTGAGACTTAGATGAATTCACAGCAGAAGAAGCCACAGGAGAATCTAGGCCCTCTGGATACG