VISDB Viral Integration Site DataBase

VIS ID

TVIS10012298

Fusion event

HBV-WWTR1 integration

Validated

No

Detection method

NGS

Data source

Curated

Sample type

Disease

Hepatocellular carcinoma (HCC)

Quality evaluation

Normal

Reported year

2018

PubMed ID

Virus name

HBV

Reference genome

Region type

X protein|

Start

1791

Orient

-

Integrated sequence

CCGACCTTGAGGCATACTTCAAAGACTGTTTGTTTAAAGACTGGGAGGAGTTGGGGGAGGAGATTAGGTTAAAGGTCTTTGTACTAGGAGGCTGTAGGCA| |TAAATTGGTCTGCGCACCAGCACCATGCAACTTTTTCACCTCTGCCTAATCATCTCTTGTTCATGTCCTACTGTTCAAGCCTCCAAGCTGTGCCTTGGGT

Chromosome

chr3

Cytoband

q25.1

Reference genome

Start

End

149434832/149717045 (Hg38)

Orient

+

Location type

Intronic

Fragile sites / regions

Target gene

miRNAs that regulate target gene

hsa-mir-193b-3p ; hsa-mir-335-5p ; hsa-mir-18a-5p ; hsa-mir-374a-3p ; hsa-mir-488-3p ; hsa-mir-3148 ; hsa-mir-361-5p ; hsa-mir-4635 ; hsa-mir-873-5p ; hsa-mir-374b-5p ; hsa-mir-374a-5p ; hsa-mir-5682 ; hsa-mir-200b-5p ; hsa-mir-200a-5p ; hsa-mir-5692c ; hsa-mir-5692b ; hsa-mir-369-3p ; hsa-mir-101-5p ; hsa-mir-6871-3p ; hsa-mir-29c-3p ; hsa-mir-29b-3p ; hsa-mir-29a-3p ; hsa-mir-3121-3p ; hsa-mir-6513-5p ; hsa-mir-887-5p ; hsa-mir-3913-5p ; hsa-mir-3122 ; hsa-mir-450a-1-3p ; hsa-mir-6780a-5p ; hsa-mir-6779-5p ; hsa-mir-3689c ; hsa-mir-3689b-3p ; hsa-mir-3689a-3p ; hsa-mir-30b-3p ; hsa-mir-1273h-5p ; hsa-mir-6788-5p ; hsa-mir-30c-2-3p ; hsa-mir-30c-1-3p ; hsa-mir-7977 ; hsa-mir-6799-5p ; hsa-mir-6883-5p ; hsa-mir-6785-5p ; hsa-mir-4728-5p ; hsa-mir-149-3p ; hsa-mir-7106-5p ; hsa-mir-24-3p ; hsa-mir-4746-3p ; hsa-mir-4284 ; hsa-mir-383-3p

Nearest miRNA

hsa-let-7g/Upstream/15279139; hsa-mir-1224/Downstream/1848831;

Nearest TSS

Nearest CpG islands

None/Target, chr3-CpG: 148/Upstream/58504, chr3-CpG: 45/Downstream/35077

Nearby gene

WWTR1(-13772) ; COMMD2(+21425) ;

Nearest cancer related gene

WWTR1(OG, No orient, 0)

Upstream sequence

cctgtaatcccagcactttctgaggccgaggcgggcggatcacaaggtcaggagatcaagaccaccctggctaacacggtgaaaccccTCGATGATAGTT

Downstream sequence

tagtcccagctatctgggggctgacgtgggaggattgcttgagctggggaggttgaggctgcagcgagctgagattgtgcgactccccagtgggtgacag