Basic Information
VIS ID
TVIS10012304
Fusion event
HBV-chr3 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
X protein|Polymerase|
Start
1518
Orient
+
Integrated sequence
TCCTTTGTTTACGTCCCGTCGGCGCTGAATCCTGCGGACGACCCTTCTCGGGGTCGCTTGGGACTCTCTCGTCCCCTTCTCCGTCTGCCGTTCCGACCGA| |CCACGGGGCGCACCTCTCTTTACGCGGACTCCCCGTCTGTGCCTTCTCATCTGCCGGACCGTGTGCACTTCGCTTCACCTCTGCACGTCGCATGGAGACC
Host Sequence
Chromosome
chr3
Cytoband
p24.3
Reference genome
GRCh37/hg19
Start
19696364/19654872 (Hg38)
End
19696364/19654872 (Hg38)
Orient
+
Location type
Intergenic
Nearest miRNA
hsa-mir-12127/Upstream/339941; hsa-let-7g/Downstream/482693;
Nearest TSS
ENST00000440867/Upstream/307151; ENST00000443878/Downstream/243952;
Nearest CpG islands
None/Target, chr3-CpG: 148/Upstream/506264, chr3-CpG: 87/Downstream/291969
Nearby gene
KCNH8(-119229) ; EFHB(+224602) ;
Upstream sequence
GGGTAACAGAACCAAAGTATCAAAATCTTCTTAACATGGTATAAATATATTAAAGAGCCCAGCAAATAAATCTAATAACTAGAAAGAATCATGAAAGAAT
Downstream sequence
atccaggcattttcatatatcctctgaaatctaggcaaagattcccagacctcaattcttgccttctgcacactgcaggtccaacaccacatggaagctg
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
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