Basic Information
VIS ID
TVIS10012311
Fusion event
HBV-LOC105377384 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
X protein|
Start
1731
Orient
-
Integrated sequence
ACCAAATATTGCCCAAGGTCTTACATAAGAGGACTCTTGGACTCTCAGCAATGTCAACGACCGACCTTGAGGCATACTTCAAAGACTGTTTGTTTAAAGA| |CTGGGAGGAGTTGGGGGAGGAGATTAGGTTAAAGGTCTTTGTACTAGGAGGCTGTAGGCATAAATTGGTCTGCGCACCAGCACCATGCAACTTTTTCACC
Host Sequence
Chromosome
chr4
Cytoband
q26
Reference genome
GRCh37/hg19
Start
117266755/116345599 (Hg38)
End
117266755/116345599 (Hg38)
Orient
-
Location type
Intronic
Target gene
LOC105377384
Nearest miRNA
hsa-mir-12113/Upstream/1688745; hsa-mir-1305/Downstream/9161660;
Nearest TSS
ENST00000502981/Upstream/46723; ENST00000420701/Downstream/145601;
Nearest CpG islands
None/Target, chr4-CpG: 46/Upstream/1745823, chr4-CpG: 21/Downstream/253676
Nearby gene
MIR1973(-45831) ; TRAM1L1(+737955) ;
Upstream sequence
AAGTGATGCTGTCACTTCCAAAAGGTATCGCTTTACCGTTAACACCAGTATAATAAATATCCATCATGCCCTACTTTTGAATAATATCTATTTGATTAAT
Downstream sequence
GTATTAACATAGGCAAGAGGAAAGAATACCAGGTAGAATTATCTTTTACCCCCATGATCTTCCCCTTGGTTGAGCCTGACCTCATCCTCTGCATTAAAAG
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
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