VISDB Viral Integration Site DataBase

VIS ID

TVIS10012312

Fusion event

HBV-ELF2 integration

Validated

No

Detection method

NGS

Data source

Curated

Sample type

Disease

Hepatocellular carcinoma (HCC)

Quality evaluation

Normal

Reported year

2018

PubMed ID

Virus name

HBV

Reference genome

Region type

X protein|

Start

1753

Orient

-

Integrated sequence

ACATAAGAGGACTCTTGGACTCTCAGCAATGTCAACGACCGACCTTGAGGCATACTTCAAAGACTGTTTGTTTAAAGACTGGGAGGAGTTGGGGGAGGAG| |ATTAGGTTAAAGGTCTTTGTACTAGGAGGCTGTAGGCATAAATTGGTCTGCGCACCAGCACCATGCAACTTTTTCACCTCTGCCTAATCATCTCTTGTTC

Chromosome

chr4

Cytoband

q31.1

Reference genome

Start

End

139991198/139070044 (Hg38)

Orient

+

Location type

Intronic

Target gene

miRNAs that regulate target gene

hsa-mir-4668-3p ; hsa-mir-1277-5p ; hsa-mir-297 ; hsa-mir-3924 ; hsa-mir-190a-3p ; hsa-mir-567 ; hsa-mir-5011-5p ; hsa-mir-106b-3p ; hsa-mir-410-3p ; hsa-mir-3163 ; hsa-mir-409-3p

Nearest miRNA

hsa-mir-12113/Upstream/13562737; hsa-mir-1305/Downstream/4273416;

Nearest TSS

Nearest CpG islands

None/Target, chr4-CpG: 46/Upstream/53770, chr4-CpG: 18/Downstream/12870

Upstream sequence

CCAAAAGGTATCGCTTTACCGTTAACACCAGTATAATAAATATCCATCATGCCCTACTTTTGAATAATATCTATTTGATTAATGCTGGGCATTTCCTTCC

Downstream sequence

ttggcccaggctggtcttgaactcctgagctcaagcaatcctcctgcctcagcctcccaaagtgctggaattacaggcctgagccaccacacccagccTT