ARHGAP10 _LIHC.png
Expression analysis of TCGA samples
Basic Information
VIS ID
TVIS10012314
Fusion event
HBV-ARHGAP10 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
precore/core protein|
Start
1882
Orient
+
Integrated sequence
CTGTAGGCATAAATTGGTCTGCGCACCAGCACCATGCAACTTTTTCACCTCTGCCTAATCATCTCTTGTTCATGTCCTACTGTTCAAGCCTCCAAGCTGT| |GCCTTGGGTGGCTTTGGGGCATGGACATCGACCCTTATAAAGAATTTGGAGCTACTGTGGAGTTACTCTCGTTTTTGCCTTCTGACTTCTTTCCTTCAGT
Host Sequence
Chromosome
chr4
Cytoband
q31.23
Reference genome
GRCh37/hg19
Start
148777661/147856510 (Hg38)
End
148777661/147856510 (Hg38)
Orient
+
Location type
Intronic
Target gene
ARHGAP10
miRNAs that regulate target gene
hsa-mir-17-5p ; hsa-mir-214-3p
Nearest miRNA
hsa-mir-12113/Upstream/73842; hsa-mir-1305/Downstream/4632817;
Nearest TSS
ENST00000502981/Upstream/124447; ENST00000513548/Downstream/4473;
Nearest CpG islands
None/Target, chr4-CpG: 46/Upstream/123743, chr4-CpG: 294/Downstream/585550
Upstream sequence
GTATCACAAAAGAACAATGTTTTAGCTAATTCATCATGCTGAGTTTTAAAATTATTTCTCAGTCATATATTAACTCCTATACCAGTATGTTTTTCTTAGT
Downstream sequence
ctcttgctctctgatggttcagtgtacataagctttatttcatgtacaaaattattaaaaatattgtataaaattacctttaggctatgtgtgataggtg
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
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