Basic Information
VIS ID
TVIS10012323
Fusion event
HBV-chr4 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
precore/core protein|
Start
1880
Orient
+
Integrated sequence
GGCTGTAGGCATAAATTGGTCTGCGCACCAGCACCATGCAACTTTTTCACCTCTGCCTAATCATCTCTTGTTCATGTCCTACTGTTCAAGCCTCCAAGCT| |GTGCCTTGGGTGGCTTTGGGGCATGGACATCGACCCTTATAAAGAATTTGGAGCTACTGTGGAGTTACTCTCGTTTTTGCCTTCTGACTTCTTTCCTTCA
Host Sequence
Chromosome
chr4
Cytoband
q13.3
Reference genome
GRCh37/hg19
Start
73047054/72181337 (Hg38)
End
73047054/72181337 (Hg38)
Orient
-
Location type
Intergenic
Nearest miRNA
hsa-mir-12113/Upstream/5904409; hsa-mir-1243/Downstream/4392231;
Nearest TSS
ENST00000502981/Upstream/34807; ENST00000503918/Downstream/130918;
Nearest CpG islands
None/Target, chr4-CpG: 46/Upstream/149090, chr4-CpG: 34/Downstream/386729
Nearby gene
NPFFR2(-33136) ; ADAMTS3(+99632) ;
Upstream sequence
tgataggagcaccaaccctattataaactgcatgtggaagtgatctaggttgtgtgctccttatgagaatctaatgcctgatgatctgtcactgtttccc
Downstream sequence
ATTAGGGATTTTGGAAGAATTTTGACAATAATAAAAGTGACAAAAACCAAAATGATAGCCAAGGTTGCTGTGATGTGCAAAGCAGCCCGGAGATGCTTTT
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
Curate