Basic Information
VIS ID
TVIS10012325
Fusion event
HBV-chr5 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
Virus Sequence
Virus name
HBV
Reference genome
Region type
Polymerase|large S protein|middle S protein|
Start
40
Orient
-
Integrated sequence
AATTCCACAACCTTCCACCAAACTCTGCAAGATCCCAGAG| |TGAGAGGCCTGTATTTCCCTGCTGGTGGCTCCAGTTCAGGAACAGTAAACCCTGTTCTGACTACTGCCTCTCCCTTATCGTCAATCTTCTCGAGGATTGG
Host Sequence
Chromosome
chr5
Cytoband
q21.2
Reference genome
End
104348899/105013198 (Hg38)
Orient
-
Location type
Intergenic
Fragile sites / regions
Nearest miRNA
hsa-mir-10397/Upstream/4196633; hsa-mir-103a-1/Downstream/5500631;
Nearby gene
NUDT12(-1450409) ; RAB9BP1(+86276) ;
Upstream sequence
gagattggagggcaggagaggagaacgtatagtacatttcccccttctccctccctagattgcttctttggcagtggttgtttctcctctatggccgcag
Downstream sequence
TGAGAAGAGCCATCTTAGGATAAAAATAACAACATGGAAGGTAGAGAAAAGGCCTGGAAAGCAAACAGGTCTTTGGTGTCAATCTTTTACTAAATATAGG
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
Curate