Basic Information
VIS ID
TVIS10012327
Fusion event
HBV-LOC105379110 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
X protein|precore/core protein|
Start
1818
Orient
+
Integrated sequence
GTTTGTTTAAAGACTGGGAGGAGTTGGGGGAGGAGATTAGGTTAAAGGTCTTTGTACTAGGAGGCTGTAGGCATAAATTGGTCTGCGCACCAGCACCATG| |CAACTTTTTCACCTCTGCCTAATCATCTCTTGTTCATGTCCTACTGTTCAAGCCTCCAAGCTGTGCCTTGGGTGGCTTTGGGGCATGGACATCGACCCTT
Host Sequence
Chromosome
chr5
Cytoband
q21.3
Reference genome
GRCh37/hg19
Start
104650325/105314624 (Hg38)
End
104650325/105314624 (Hg38)
Orient
-
Location type
Intronic
Fragile sites / regions
FRA5F
Target gene
LOC105379110
Nearest miRNA
hsa-mir-10397/Upstream/4498059; hsa-mir-103a-1/Downstream/5199205;
Nearest TSS
ENST00000502646/Upstream/68260; ENST00000513676/Downstream/78346;
Nearest CpG islands
None/Target, chr5-CpG: 87/Upstream/2054775, chr5-CpG: 253/Downstream/2354805
Nearby gene
RAB9BP1(-214526) ;
Upstream sequence
CCCTTTAAGAAATAAAGGACATTTGAGTCCAATGAAAATTTTAAATTATGATAGTTCAGTGCCACAGAAGAAATAAATAAATCATGCTTATTTGAAAGAA
Downstream sequence
tttgctaatattttgttgaggatatttgcatatatattcataaagatgatttgtctgtagttttattttgatttagacatgagggtaatgctgtcttcct
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
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